GSN and acute respiratory distress syndrome: Administration of recombinant human plasma GSN (rhu-pGSN) has been shown to attenuate lung injury and improve survival in various ALI/ARDS models, including LPS-induced ALI, ventilator-induced lung injury (VILI), and hyperoxia-induced lung injury (DiNubile et al., 2002; Christofidou-Solomidou et al., 2003a; Rothenbach et al., 2004).