The number of muscle adverse events associated with colchicine that generated a signal were as follows:16 cases of toxic myopathy (ROR 32.50, 95% CL 19.74–53.51; IC 4.97 95% CL 1.89–5.10); 128 cases of myopathy 16.82 (ROR 16.81, 95% CL 14.11–20.04; IC 4.04 95% CL 3.29–4.46); 211 cases of rhabdomyolysis (ROR 5.76, 95% CL 5.02–6.60; IC 2.50 95% CL 2.02–2.92); and necrotizing myositis, muscle necrosis, and myoglobinuria, with fewer than three reported cases of urinary myoglobin detection, myoglobinuria, and blood myoglobin detection, which did not qualify for generating the signal conditions. This evidence concerns the gene MB and rhabdomyolysis.