Further analysis of the muscle-related ADRs associated with the use of statins revealed that the five most common ADRs were necrotizing myositis in 438 cases (ROR 50.47, 95% CL 41.74–61.01; IC 3.70 95% CL 3.25–4.08); myopathy in 3197 cases (ROR 12.60, 95% CL 12.03–13.20; IC 2.91 95% CL 2.77–3.05); rhabdomyolysis 14,716 cases (ROR 11.95, 95% CL 11.70–12.21; IC 2.86 95% CL 2.79–2.92); blood myoglobin was elevated in 528 cases (ROR 10.53, 95% CL 9.43–11.74; IC 2.76 95% CL 2.41–3.08); muscle necrosis 276 cases (ROR 9.40,95% CL 8.10–10.90; IC 2.66 95% CL 2.17–3.09). The gene discussed is MB; the disease is rhabdomyolysis.