RIPK1 and colitis: Notably, these polysaccharides exerted pronounced inhibitory effect on the necroptosis signaling cascade involving receptor-interacting protein kinase receptor-interacting protein kinase 1/receptor-interacting protein kinase 3/mixed kinase-region-like proteins (RIPK1-RIPK3-MLKL), resulting in decreased levels of phosphorylated MLKL in colitis mice.