c-CBL has recently been found as a direct phosphorylated target of Pollo-like kinase 1 (PLK1) in tyrosine kinase inhibitor (TKI) -sensitive EGFR-mutant NSCLC cells, and PLK1 influences the stability of c-CBL in a manner dependent on its kinase activity. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.