Applying eQTLs for baicalin-related targets, we performed MR analysis in discovery and replication cohorts and identified eight therapeutic targets causally associated with T2DM: ANPEP, BECN1, HNF1A, ST6GAL1, PGF, RXRA, SREBF1, USP7. This evidence concerns the gene SREBF1 and type 2 diabetes mellitus.