Genetic prediction indicated elevated levels of AKT2, AMD1, ANPEP, BECN1, CA4, CLC, F10, FGF2, HNF1A, MPO, MYC, NOS3, P2RX4, ST6GAL1 and USP7 were associated with increased risk of T2D, while the concentrations of CASP1, CD38, CDA, DHFRL1, FKBP1B, FPGS, HES1, KDM5A, NCOA1, NFKB1, PGF, PRMT3, RELA, RXRA, SREBF1, and UCK2 exhibited a negative correlation with T2D risk. Here, DHFR2 is linked to type 2 diabetes mellitus.