Applying eQTLs for baicalin-related targets, we performed MR analysis in discovery and replication cohorts and identified eight therapeutic targets causally associated with T2DM: ANPEP, BECN1, HNF1A, ST6GAL1, PGF, RXRA, SREBF1, USP7. The gene discussed is HNF1A; the disease is type 2 diabetes mellitus.