F2R and adult acute megakaryoblastic leukemia: In a previous study, we developed an image-based assay to measure morphological changes in the human megakaryoblastic leukemia cell line MEG-01 cells and showed that MEG-01 cells express functional PAR1 and PAR4, and that activation of both PAR1 and PAR4 induces morphological changes in MEG-01 cells (Heo et al., 2022a).