MAPT and tauopathy: Despite testing multiple different experimental paradigms, we found that Drosophila are remarkably resistant to the trans-synaptic tau spread evidenced in human tauopathies and observed in mammalian model systems.3-12,16,17,21,22,58,59 These important negative data demonstrate that, while exceptionally useful for a number of other studies in neurodegeneration, including modifiers of tau toxicity,60-63  Drosophila are unlikely to be a suitable model for screening modifiers of trans-synaptic tau spread.