In their publication, the authors did notfind [4] an increase of serum F, only a decreaseof E and renin, and this discrepancy highlights the complexity of the regulation of F and E.11βHSD1 is expressed in many tissues, playing a physiological role in healthy people and apathological one in many diseases, particularly in inflammatory situations, such as obesity,hypertension, and aging, three clinical situations where E and renin were lower [2]. The gene discussed is REN; the disease is obesity due to melanocortin 4 receptor deficiency.