Here, healthy donor neutrophils from one donor were cultured in autologous plasma; and plasma from 12 IBD patients with active disease (6 UC/6 CD; blood C-reactive protein median 48 mg/ml; stool calprotectin median 1067 μg/g) and 12 patients in clinical remission (blood C-reactive protein median 1 mg/ml; stool calprotectin median 95 μg/g) for 4 hours (Figure 5D). This evidence concerns the gene CRP and inflammatory bowel disease.