INS and Hypoglycemia: ,5 Nonetheless, combining SGLT2is with insulin or agents that stimulate insulin production (like glinides and sulfonylureas) could elevate hypoglycemia risk; therefore, it has been recommended to lower the dosage of sulfonylureas or glinides by half or reduce basal insulin by 20% upon initiating SGLT2i treatment, particularly if the patient's HbA1C is within the normal range or if they have a history of hypoglycemia.33