GPT and liver disorder: Immunotolerance is an outdated term and is being replaced by other terms such as chronic infection with high replication, low inflammation, or simply HBeAg+ “chronic infection.” “Immunotolerance” in patients with CHB was formerly described as HBeAg positivity, high viral replication often with serum HBV-DNA levels >106-7 IU/ ml, persistently normal ALT, and no or minimal evidence of liver disease on histopathology.