The variant of PBX1, E2A-PBX1, which is generated by the fusion of E2A and PBX1 in the process of chromosomal translocation, is associated with pre-B-cell acute lymphoblastic leukemia (ALL) (Izraeli et al., 1992; Izraeli et al., 1993; Nagel and Meyer, 2022; Mostufi-Zadeh-Haghighi et al., 2023; Sinclair et al., 2023). Here, PBX1 is linked to acute lymphoblastic leukemia.