PBX1, initially identified for its role in childhood acute lymphoblastic leukemia, has since been implicated in the overexpression of various solid tumors, including esophageal cancer, breast cancer, melanoma, adrenocortical carcinoma, prostate cancer, gastric cancer, colorectal cancer, pancreatic cancer et al. (Magnani et al., 2011; Chen et al., 2012; Feng et al., 2015; Magnani et al., 2015; Francis et al., 2021; Shen et al., 2021; Dai et al., 2023; Crisafulli et al., 2024; Kao et al., 2024). Here, PBX1 is linked to acute lymphoblastic leukemia.