IFNG and influenza: A study that tracked T cell status in 342 healthy adults during the 2009 UK influenza pandemic found the strongest inverse association between IFN-γ+IL-2-CD8+ T cell frequency and disease symptom score (r = −0.6, P = 0.004), and almost all of these protective CD8+ T cells exhibited CD8+ TEM and CD8+ TEMRA phenotypes [44].