In the experiment on whether GSK‐3β inhibitor can reduce tau protein phosphorylation, neuronal apoptosis, and improve memory in APP and tau protein coexpressed mice, it was observed that TDZD can block GSK‐3β involved in neurodegenerative disease‐related proapoptotic signaling cascade, thereby improving cognitive function104, 105 and reversing hyperphosphorylated tau protein expression.106. Here, MAPT is linked to neurodegenerative disease.