AKT1 and Cognitive impairment: Besides, magnolol treatment significantly increased the protein expression ratios of p‐GSK‐3β (Ser9)/GSK‐3β and p‐Akt (Ser473)/Akt in the brain tissue of AD mice, decreased the protein levels of Aβ40 and Aβ42, and therefore significantly improved the cognitive deficits of TgCRND8 mice.159