Besides, magnolol treatment significantly increased the protein expression ratios of p‐GSK‐3β (Ser9)/GSK‐3β and p‐Akt (Ser473)/Akt in the brain tissue of AD mice, decreased the protein levels of Aβ40 and Aβ42, and therefore significantly improved the cognitive deficits of TgCRND8 mice.159. This evidence concerns the gene GSK3B and Alzheimer disease.