To further explore the tumor suppressing role of the characterized loss‐of‐function MIG6 mutants, we selected three representative ERRFI1 mutations, specifically R286Qfs*7, H393R and Y395del, which result in either MIG6 Seg1/2 mutants or a mutant with impaired phosphorylation at Y394 and Y395 residues. This evidence concerns the gene ERRFI1 and neoplasm.