EGFR‐targeted therapy is highly effective for multiple cancer types, including non‐small cell lung cancer, head and neck cancer, and colorectal cancer, particularly when they have EGFR genomic changes such as specific somatic mutations, gene amplification, or EGFR protein overexpression [5, 8, 10, 11, 13]. The gene discussed is EGFR; the disease is head and neck cancer.