The present study found that JSP suppressed the activation of the AGE-RAGE axis and the PI3K/AKT pathway, leading to improvements in renal pathologies observed in DKD, such as mesangial proliferation, basement membrane thickening, tubular epithelial cell degeneration, necrosis, and the extent of renal fibrosis. The gene discussed is AKT1; the disease is renal fibrosis.