Treatment of ACE2 activator resorcinolnaphthalein or Ang (1‐7) reduces the severity of LPS‐induced ALI and pyroptosis, while AngII, ACE2 inhibitor MLN‐4760 or Mas inhibitor A779 significantly exaggerates them, suggesting the protective role of ACE2/Ang (1‐7)/Mas axis in the pyroptosis of ALI model.162. The gene discussed is MAS1; the disease is acute respiratory distress syndrome.