In the pre‐defined set of 72 DCM genes, WES detected a single class 4–5 titin truncating variant (TTNtv) in 69 pts (18%), a single class 4–5 non‐titin variant (non‐TTN) in 56 pts (14%), only VUS in 103 pts (27%) and a negative result in 158 pts (41%). Here, TTN is linked to familial dilated cardiomyopathy.