Importantly, we confirmed among RODCM patients a strong relationship between the positive genetic test (presence of class 4–5 non‐TTN VOIs and/or class 4–5 VOIs in genes coding nuclear envelope proteins) and both the primary outcome (death/progressive heart failure) and the secondary outcome (life‐threatening ventricular arrhythmias) (Central Illustration, Figure3). This evidence concerns the gene SUN2 and Ventricular arrhythmia.