Based on genetic assessment, individuals with LVRR at the final follow‐up had less frequent history of familial DCM (18 vs. 32%, P < 0.01) and a lower prevalence of both class 4–5 non‐TTN VOIs (5 vs. 16%, P < 0.01) and class 4–5 VOIs in genes coding nuclear proteins (0 vs. 5%, P < 0.05), which affected exclusively the gene RBM20. This evidence concerns the gene RBM20 and familial dilated cardiomyopathy.