Thus, in our study, to explore AGTPBP1 function in PC, we firstly examined its mutations, structural variant, and putative copy-number alterations (CNAs) from the GISTIC (Genomic Identification of Significant Targets in Cancer) algorithm across cancers in 5 pancreatic adenocarcinoma studies with 988 samples using the cBioPortal analysis. The gene discussed is AGTPBP1; the disease is pachyonychia congenita.