Using SH-SY5Y cells exposed to high glucose concentrations to induce hyperglycemia, disruptions in glucose sensing leads to activation of the phosphorylated protein kinase B (pAkt)/GSK-3β signaling pathway, and increased expression of BACE and Aβ42, an effect that can be reversed via pretreatment with melatonin [62]. The gene discussed is GSK3B; the disease is Hyperglycemia.