Breast cancer exhibits various molecular subtypes, including Luminal A, Luminal B, HER2 positive, and triple negative.1017,1018 Nanobiosensors have demonstrated great potential in the detection of a variety of biomarkers, circulating tumor cells, and other unique biomolecules in diagnosis of breast cancer.1019–1023 MicroRNA miR-99a-5p dysregulation has been identified as a reliable indicator of early breast cancer. This evidence concerns the gene ERBB2 and breast carcinoma.