TP53 and lung carcinoma: V-Ki-ras2 Kirsten ratsarcoma viral oncogene homolog (KRAS) and epidermal growth factor receptor (EGFR) were the most frequent mutations observed, along with p53, Kelch-like ECH-associated protein 1 (Keap1), serine/threonine kinase 11 (STK11), and neurofibromatosis 1 (NF1) as tumor suppressor genes.498,499 The expression of EGFR is significantly high in over 70 to 80 percent of NSCLC, making it a crucial focus for the treatment of lung cancer.500–502