CALCA and medullary thyroid gland carcinoma: Omer et al. designed a kind of gold nanobiosensor in the sol-gel/PEG matrix to detect the calcitonin, which is secreted by neuroendocrine C cells, functioning as an excellent biomarker for early diagnosing MTC.1012 By assessing calcitonin in serum, the method offered a convenient possibility of MTC early diagnosis as well as evaluating therapeutic effects of treatment.