Some studies have found that IL-6-mediates the interactions between gastrointestinal tumor cells and CAF by promoting the activation of fibroblasts.411 Salimifard et al. delivered IL6 specific siRNA through hyaluronic acid PEG chitosan lactate (H-PCL) nanoparticles (NPS), which could inhibit the proliferation and metastasis of CT26 cells and inhibit cancer progression.412. Here, IL6 is linked to cancer.