SPP1 and neoplasm: Studies have shown that tumor-promoting TAMs have stronger phagocytic ability.722–725 The migration and invasion capabilities of glioma-related microglia and macrophages are enhanced during the polarization process of M1/M2, thanks to the release of lactadherin and osteopontin by tumor cells, which promote the contraction of actin filaments and rearrangement of microtubules.