Following the administration of CLANs through intravenous injection, the CML mouse model showed enhanced survival due to the presence of pCas9/gRNA targeting BCR-ABL.785 Hong et al. created a novel combination of viral and nonviral chimeric nanoparticles (ChNPs) that effectively target both crucial BCR-ABL-related pathways. This evidence concerns the gene ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive.