In the AML animal model, the use of NPs greatly decreased the presence of leukemia cells in both the bone marrow and circulating blood, effectively preventing the spread of leukemia cells to extramedullary organs.758 To obtain intelligent NPs, the researchers loaded FA-HSA-ATO, which stands for folic acid (FA)-labeled human serum albumin (HSA), with ATO. Here, ALB is linked to acute myeloid leukemia.