EGFR and neoplasm: By simultaneously capturing exosomal RNA/DNA and cfDNA, the sensitivity of detecting the T790M mutation achieved 92%, and the specificity achieved 89%.529 Krug et al. also demonstrated that exosomal RNA combined with cfDNA can improve the sensitivity of EGFR mutation detection in patients with NSCLC, especially in metastatic patients with low circulating tumor DNA levels; the sensitivity increased from 26% to 74%.530