The YPC vector has high gene transfer ability to EGFR-positive hepatoma cells, promoting AChE gene expression and significantly inhibiting liver cancer in vivo and in vitro by inhibiting p-ERK and cyclin D1.409 Activated hepatic stellate cells (AHSC) promote the activation of immunosuppressive cells such as M2 and MDSC and form a matrix barrier to restrict the migration and function of T cells through CXCL12/CXCR4 and various growth factors such as TGF-β, which creates a favorable environment for tumor growth. Here, EGFR is linked to hepatocellular carcinoma.