Moreover, the molecular mechanism has been studied in that miR-30a and miR-30b were overexpressed after LDR treatment in NSCLC, which could downregulate the expression of plasminogen activator inhibitor-1 (PAI-1).589 The advancement of nanotechnology has significantly broadened the use of radiotherapy for lung cancer.590,591. This evidence concerns the gene SERPINE1 and non-small cell lung carcinoma.