The pre-targeting mechanism comprised of dibenzocyclooctyne-modified anti-CD20 and anti-Lym1 antibodies used as tumor-targeting elements, along with azide-modified BEZ235.The research showed that the dual antibody pre-targeting approach successfully enhanced the amount of nanoparticles remaining in the tumor cells of interest, and enhanced the anti-cancer effectiveness of BEZ235 by blocking the PI3K/mTOR pathway.801. Here, MTOR is linked to cancer.