Nanomedicines are emerging as promising breast cancer therapeutic agents that could correct drugs defects and ensure precise drug distribution.1067–1071 Zhang et al. created the PPD self-assembling dendrimer nanosystem, which was coated with an anti-PD-L1 antibody and used to deliver a small interfering RNA (siRNA) to target PDK1. This evidence concerns the gene PDK1 and breast carcinoma.