The α-peptide-NP drug delivery platform solves the problem of melittin delivery, regulates hepatic sinusoidal endothelial cells (LSECs), breaks the inherent tolerance of the liver, and activates LSECs that can mediate immune cell recruitment and reverse the inhibition of other immune cells.437 In view of the poor immunogenicity of pancreatic cancer, Li et al. constructed a mixed micellar delivery system targeting M2 tumor-associated macrophages, which specifically blocked PI3K=γ and colony stimulating factor-1 receptor (CSF-1R) pathways. Here, CSF1R is linked to pancreatic neoplasm.