Schizophyllan (SPG), a soluble β-1,3-glucan extracted from Schizophyllan commune, is recognized as a dectin-1 ligand capable of effectively delivering brief DNA sequences into immune cells like macrophages and dendritic cells.684 Further, recent research has indicated that SPG NPs can function as a dectin-1 ligand that is not an agonist, facilitating the transfer of the payload to TLR9 within the body.685 Thus, Tiwari et al. evaluated the effects of C6 rat glioblastoma cells by using the fungal polymer SPG to load CpG ODN 1826 into prepared NPs. This evidence concerns the gene CLEC7A and glioblastoma.