KCNH2, also known as Kv11.1 or hERG1, represents a prominent member of the Kv channel family.16 Expressed in various tissues, including intestinal K and L cells, KCNH2’s association with hypoglycemia as a side effect of its blockers suggests a potential role in regulating blood glucose homeostasis.17,18 Despite this, the precise involvement of KCNH2 in the regulation of incretin hormone secretion in enteroendocrine cells remains elusive. This evidence concerns the gene KCNH2 and Hypoglycemia.