Targeting MIRO1 in neurons is likely to be highly toxic as MIRO1 is critical to neuronal development and prevention of neurodegeneration, with germline MIRO1 KO mice developing cyanosis and dying within 15 to 30 min after birth and neuronal-conditional MIRO1 KO leading to early onset of motor neuron disease (72). Here, RHOT1 is linked to motor neuron disorder.