We know that splice errors that lead to the production of abnormal transcripts rarely occur in normal cells, but research has found that they are almost the inherent characteristics of cancer cells.20 Tumor-specific splicing alterations are created by mutations that disrupt splicing-regulatory elements within genes and impair splicing recognition or by altering the RNA-binding preferences of individual splicing factors.21 Apoptotic chromatin condensation inducer 1 has the function of participating in splicing-related mRNA metabolism, but it is rarely reported that Acin1 participates in HCC. This evidence concerns the gene ACIN1 and hepatocellular carcinoma.