This study indicated that the expression of miR-674-5p was significantly downregulated in the liver damaged by cona.28 In our study, miR-674-5p is downregulated in HCC, while Acin1 is upregulated in HCC, which shows that miR-674-5p is likely to regulate the upregulation of Acin1. The gene discussed is ACIN1; the disease is hepatocellular carcinoma.