The previous paper also reported that the HOTAIR level in HCC tissues was correlated to tumor node metastasis, extrahepatic metastasis, vascular invasion, and tumor size.25 High expression of HOTAIR in HCC tissues indicated a significantly short recurrence-free survival.19 In assistance with this data, we considered that HOTAIR might be a suitable predictive biomarker for HCC diagnosis and prognosis. This evidence concerns the gene HOTAIR and neoplasm.