IGFL2 and cancer: As is well known, lncRNAs have also been reported to predict the outcomes of patients with various cancers, especially digeative cancer.24 The lncRNAs play an essential role in the progression of CRC, which could interfere with CRC cell proliferation, invasion, tumor growth, and metastasis.25 For example, lncRNA IGFL2-AS1 was identified as a tumor promoter in CRC that promoted malignant growth of HCT116 cells via modulating the miR-433-3p/PAK4 axis.26 FAM30A has received widespread attention in other tumors.