The most prevalent stromal tumors in the gastrointestinal tract are GISTs, which develop from Cajal’s interstitial cells.9 A GIST may be brought on by oncogenic mutations in the CD117 (KIT) or platelet-derived growth factor receptor alpha (PDGFRα) genes.10 Over 95% of GISTs express the c-KIT proto-oncogene, CD117, and 70%-90% of GISTs express the human hematopoietic progenitor cell marker, CD34. The gene discussed is KIT; the disease is gastrointestinal stromal tumor.