In addition, Chen et al31 demonstrated that cytochrome P450 (CYP) 1B1 (CYP1B1)-derived 20-HETE promoted the ubiquitination and degradation of acyl-CoA synthetase long-chain family member 4 (ACSL4), ultimately inducing tumor cell resistance to ferroptosis, and the inhibition of CYP1B1 sensitized tumor cells to an anti-PD-1 antibody. This evidence concerns the gene ACSL4 and neoplasm.