EGFR and cancer: MC-38 is the third most common cancer and the second leading cause of cancer-related death worldwide.25 The difficulty of early screening, and the tendency to metastasize further augmented the bottleneck of CRC treatment.26 Drug 5-fluorouracil is the first line of chemotherapy in CRC, and many drugs, such as EGFR inhibitors, have also been investigated to block these processes in CRC.