MC-38 is the third most common cancer and the second leading cause of cancer-related death worldwide.25 The difficulty of early screening, and the tendency to metastasize further augmented the bottleneck of CRC treatment.26 Drug 5-fluorouracil is the first line of chemotherapy in CRC, and many drugs, such as EGFR inhibitors, have also been investigated to block these processes in CRC. This evidence concerns the gene EGFR and colorectal carcinoma.