Therefore, biochemical analysis of oxidative damage and antioxidant biomarkers glutathione peroxidase (GPx), malondialdehyde (MDA), superoxide dismutase inhibition (SOD), myeloperoxidase (MPO), and catalase (CAT) levels, together with histopathological evaluation, reveals the positive efficacy of treatments applied against ulcerative colitis at the tissue level. This evidence concerns the gene MPO and ulcerative colitis.