SOD3 and neoplasm: Moreover, SOD3 overexpression can inhibit cell growth and metastasis in prostate, pancreatic, thyroid, and lung cancers,15,32,40,41 and also inhibits tumor metastasis in a metastasis mouse model.42 Herein, SOD3 overexpression limited the proliferative, migrative, and invasive capabilities of CRC cells and also prevented tumor growth and liver metastasis.