Moreover, SOD3 overexpression can inhibit cell growth and metastasis in prostate, pancreatic, thyroid, and lung cancers,15,32,40,41 and also inhibits tumor metastasis in a metastasis mouse model.42 Herein, SOD3 overexpression limited the proliferative, migrative, and invasive capabilities of CRC cells and also prevented tumor growth and liver metastasis. Here, SOD3 is linked to lung cancer.