Downregulated SOD3 levels have been found in breast, lung, and pancreas carcinoma.13,31,32 Loss of SOD3 expression can also contribute to tumor recurrence and poor patient outcome.33,34 Herein, SOD3 was downregulated in CRC, and its low expression was positively correlated with an unfavorable prognosis. This evidence concerns the gene SOD3 and neoplasm.