Hence, these AQPs have significant functions in the female reproductive system, participating in processes such as cervical maturation, vaginal lubrication, implantation, egg transport, inhibition of uterine water, oocyte cryopreservation, follicle maturation, and blastocyst formation.84 Specifically, AQP1 may potentially be involved in endometriosis through modulation of the Wnt/β-catenin signaling pathway.85 AQP2 is found in the endometrial tissues of patients with endometriosis and EC 2 estrogen-dependent diseases. Here, AQP2 is linked to endometriosis.