Aquaporins are a family of small membrane proteins that preserve airway fluid homeostasis and interact with asthma, airflow obstruction, pulmonary edema, inflammation, and other environmental factors.63Juglans regia was shown to improve allergic asthma by inhibiting inflammatory cytokines and elevating protein expression levels of AQP-4, and AQP-5.64 Another study stated that AQP3 potentiated ovalbumin-induced mouse asthma by facilitating H2O2 membrane permeability, increasing chemokine production (CCL22 and CCL24), and T cell trafficking from alveolar macrophages.65 The gene discussed is CCL22; the disease is asthma.