Acute kidney injury is the leading cause of death from sepsis, caused by an abnormal inflammatory response to infection.90 In the kidney, 8 AQPs, including AQP1-AQP7 and AQP11, which play a role in tissue development, metabolism, and regulation of urine concentration, are found in different cells and segments.91 One study proposed that in a mouse model of sepsis induced by CLP, the expression of AQP2 was downregulated through NF-κB, potentially leading to acute renal failure in sepsis.59 Renal ischemia/reperfusion (I/R) injury is a prevalent cause of AKI. The gene discussed is AQP2; the disease is acute kidney injury.