Consequently, apical AQP8 immunolabeling is diminished in the surface epithelium or crypts in the colon of IBD patients.75 In the human colon, AQP3 expression is primarily observed in mucosal epithelial cells, as indicated by a particular study.76 Moreover, findings indicate that AQP7 and AQP8 are situated on the apical side, contrasting with AQP3’s basolateral localization. This evidence concerns the gene AQP3 and irritable bowel syndrome.