AQP3 and irritable bowel syndrome: Enteritis is marked by aberrant water and electrolyte transport phenomena, coupled with inflammation and damage to the intestines.74 In the early stages of inflammatory bowel disease (IBD), a diminished mRNA expression of several AQPs, such as AQP1, AQP3, AQP7, and AQP8, has been evidenced in the human intestinal mucosa, encompassing ulcerative colitis and Crohn’s disease.