Otitis media (OM) denotes inflammation of the middle ear (ME), irrespective of the underlying mechanism or cause.72 Alterations in the water and electrolyte composition within the mucosa of the ME may give rise to otorrhea and ME effusion, potentially contributing to the onset and persistence of ME diseases, including OM.6 Eleven AQP types, ranging from AQP1 to AQP11, have been identified to be expressed in the ME and eustachian tube through techniques such as immunohistochemistry or Western blotting. Here, AQP1 is linked to ocular melanoma.