Enteritis is marked by aberrant water and electrolyte transport phenomena, coupled with inflammation and damage to the intestines.74 In the early stages of inflammatory bowel disease (IBD), a diminished mRNA expression of several AQPs, such as AQP1, AQP3, AQP7, and AQP8, has been evidenced in the human intestinal mucosa, encompassing ulcerative colitis and Crohn’s disease. This evidence concerns the gene AQP8 and irritable bowel syndrome.