In the Roessler Liver 2 dataset,11 we found an increased mRNA expression of S100P, S100A6BP, and S100A10 in HCC, and in the Roessler Liver dataset,11 we detected elevated mRNA expression of S100P, S100A6, S100A6BP, S100A10, and S100A11 in HCC tissues relative to normal tissues. Here, CACYBP is linked to hepatocellular carcinoma.