First, in HCC patients with hepatitis virus infection, elevated mRNA levels of S100A2, S100A7, S100P, and S100PBP correlated with reduced OS, whereas in HCC patients without hepatitis virus infection, elevated mRNA levels of S100A10 and S100A13 were relevant to shorter OS (Figure 5). The gene discussed is S100A2; the disease is hepatocellular carcinoma.