In HCC tissues, the mRNA levels of S100A1, S100A4, S100A6, S100A6BP, S100A9, S100A10, S100A11, S100A13, S100P, and S100PBP were upregulated, while the mRNA levels of S100G, S100A5, S100A7, S100A8 and S100A12 were downregulated (Figure 2). The gene discussed is S100A5; the disease is hepatocellular carcinoma.