IL1B and diabetes mellitus: Investigating the efficacy of biological agents such as resveratrol and melatonin may provide a very important threshold to be overcome in the management of DM.2,3 Interleukin-1 beta (IL-1β), interferon gamma (IFN-γ) resveratrol and melatonin may provide a very important threshold to be overflammation of the pancreas and induce the release of beta-defensins.