AKT1 and hypothyroidism: Hypothyroidism is associated with insufficient levels of these chemicals.1,2 Thyroid hormones either bind to their nuclear receptors and activate transcriptional activation, or they activate the Pi3k-Akt/Gsk3ß and mitogen-activated protein kinase (MAPK) signaling pathways through the cell-surface protein known as the avß3 integrin receptor.3-5