These results showed that the hypothyroidism group significantly differed from the control group in the levels of mRNA expression of the Gsk3ß and Akt1 genes after LTP recording in stimulated hippocampus tissue, whereas the levels of mRNA expression of the Cdk5, Mapt, P35 (Anxa), Capn1, Bace1, and Psen2 genes showed no significant difference between the groups. The gene discussed is CDK5; the disease is hypothyroidism.