In another recent population-based study of 166 patients, six pathogenic variants, with four being newly discovered, were identified in the lethal regions of COL1A1 and COL1A2 genes in seven patients with non-lethal OI, adding to the prior reported individuals that indicated not all glycine substitutions located in the lethal domain lead to a fatal outcome [11]. The gene discussed is COL1A2; the disease is osteogenesis imperfecta.