Impaired osteoblasts differentiation is a common features of OI types XII, XIV, XV, XVI, XVII, XVIII, caused by recessive mutations in SP7, TMEM38B, WNT1, CREB3L1, SPARC and MBTPS2. WNT1 also causes less severe dominantly inherited bone fragility. Here, CREB3L1 is linked to osteogenesis imperfecta.