Data came from the following trials of osteoporosis medications: 10 bisphosphonate,17,25,27–29,36–40 1 odanacatib,41 2 hormone therapy—1 conjugated equine oestrogen18 and 1 conjugated equine oestrogen plus medroxyprogesterone acetate,16 3 parathyroid hormone -PTH receptor agonists14,15,19, 1 denosumab,31 4 selective estrogen receptor modulator,26,32–34 and 1 romosozumab.13 The gene discussed is ESR1; the disease is osteoporosis.