AS01 adjuvant can promote robust immune responses during vaccination with CSP, the target antigen in the recently licensed P. falciparum pre-erythrocytic vaccine RTS,S; vaccination with CSP virus-like particles formulated in AS01 (RTS,S/AS01E vaccine) induced high anti-CSP serum levels in malaria-naive subjects27 and conferred protection against clinical malaria in young African children28. This evidence concerns the gene DNAJC5 and malaria.