Additionally, the number of Ki67-positive cells was significantly increased in Hesx1Cre/+; Ctnnb1lox(ex3)/+; Trp53fl/fl in comparison with Hesx1Cre/+; Ctnnb1lox(ex3)/+; Trp53fl/+ tumours (unpaired t test, P = 0.0241) (Fig. 4F). Here, MKI67 is linked to neoplasm.