CXCL1 and neoplasm: The absence of CD14-positive cells within the tumour epithelium in ACP is unexpected as the β-catenin-accumulating epithelial whorls (cell clusters) express a variety of chemo-attractant cytokines (e.g., members of the CCL and CXCL family of chemokines including CCL2, CXCL1, CXCL3, CXCL11) [22, 36, 38].