Quantification of p-ERK1/2-positive cells showed a trend of decreased positivity in both Hesx1Cre/+; Ctnnb1lox(ex3)/+; Trp53fl/fl and Hesx1Cre/+; Ctnnb1lox(ex3)/+; Trp53fl/+ tumours, although it was not significant when compared to Hesx1Cre/+; Ctnnb1lox(ex3)/+; Trp53+/+ (p = 0.2339) (Fig. 4E, G). The gene discussed is MAPK3; the disease is neoplasm.