TP53 and neoplasm: In contrast, Hesx1Cre/+; Ctnnb1lox(ex3)/+; Trp53fl/fl tumours were significantly larger (Fig. 4B, C) and histologically, showed an increase of mitotic and necrotic bodies, whereas both features were rarely observed in Hesx1Cre/+; Ctnnb1lox(ex3)/+; Trp53+/+ and Hesx1Cre/+; Ctnnb1lox(ex3)/+; Trp53fl/+ tumours (Fig. 4D).