IDH1 and glioma: Imaging features that predict the IDH mutation status in GC are in line with imaging features that generally predict IDH mutation status in glioma patients without GC; contrast enhancement, necrosis, absence of cystic change, and hemorrhage are all well-known imaging phenotypes for the differentiation of IDH-mutant gliomas from IDH-wildtype glioblastomas [22, 33].