IDH1 and glioblastoma: A significantly higher frequency of ATRX loss was also observed in GC compared with patients without GC, both in IDH-mutant astrocytomas (P = 0.020, not shown) and IDH-wildtype glioblastomas (P = 0.018, Table 2), suggesting that ATRX loss may also play a unique role in the manifestation of GC.