Because the diagnosis of IDH-wildtype glioblastomas with histological grade 2 or 3 (molecular glioblastoma) is only possible after the post-NGS era, we speculate that the true proportion of IDH-wildtype glioblastomas with histological grade 2 or 3 within these non-enhancing GCs without any additional aggressive imaging phenotype may be even greater in future studies. The gene discussed is IDH1; the disease is glioblastoma.