In breast cancer, phosphorylation of Krüppel-like factor 8 (KLF8), a key oncogene regulating gene transcription and breast cancer-related cellular processes, at Ser-80 is needed for SUMOylation at K67 upon DNA damage; this may be a novel mechanism promoting DNA repair and cell survival in breast cancer due to the inhibitory role of KLF8 SUMOylation on its transcription activity, functioning as a negative feedback [76]. The gene discussed is KLF8; the disease is breast cancer.