Another possible mechanism may involve the deacetylase, such as HDAC4, which has been considered as an E3 of SUMOylation of several proteins in breast cancer progression, such as silent information regulator 1 (SIRT1), IκBα, androgen receptor, and hypermethylated in cancer 1 (HIC1) [141–144]. The gene discussed is NFKBIA; the disease is breast carcinoma.