ZFHX3 and breast carcinoma: For example, SUMOylation at Lys-2806 of zinc finger homeobox 3 (ZFHX3) enhances the stability of ZFHX3 by interfering with its ubiquitination and proteasomal degradation, while the ZFHX3 K2806R mutant decreases its protein stability, further suppressing breast cancer growth [125].