This finding has been further confirmed by another study showing that SENP1, the major deSUMOylase often overexpressed in breast cancer tissues, leading to c-MYC deSUMOylation and the subsequent decrease in c-MYC polyubiquitination; this results in high c-MYC expression, leading to breast cancer cell proliferation and transformation [107]. The gene discussed is MYC; the disease is breast carcinoma.