In breast cancer, this type of acetylation effects metastasis, cancer cells proliferation, and the sensitivity of tumor cells to anti-tumor therapy, by regulating the functions of target proteins, such as Twist, RelA/P65, oncogene nuclear receptor coactivator amplified in breast cancer 1 (AIB1), homeobox B13 (HOXB13) [20]. The gene discussed is HOXB13; the disease is neoplasm.