FOXM1 and breast cancer: For example, the SUMOylation of forkhead box M1 (FOXM1) at multiple sites—K201, K218, K460, K478, and K495—which facilitates ring finger protein (RNF) 168 recruitment, leading to FOXM1 ubiquitination and degradation, thereby inhibiting MCF-7 cell proliferation and mitotic progression [98, 99]; this may suppress breast cancer progression, metastasis, and genotoxic agent responses [100–104].