A recent study reported that the levels of DHHC7 and DHHC21 are increased in the hippocampus of 3xTg-AD mice (a triple transgenic AD mouse model, expressing human gene mutants APPswe, PS1M146V, and tauP301L) and induce aberrant palmitoylation of key proteins that trigger Aβ aggregation in the brains of humans with AD [3, 30]. Here, ZDHHC7 is linked to Alzheimer disease.