Monocytes can be depleted using anti-CCR2 (α-CCR2) depletion antibodies.50, 57 Mice were given 20 μg α-CCR2 or the relevant isotype by i.p. injection 6 h before intranasal LPS exposure and then again on day 0 and 1 post infection (Fig. 5a). The gene discussed is CCR2; the disease is infection.