In coronary artery endothelial cells, Grx1 treatment can protect cells from hyperglycemia-induced disulfide stress and apoptosis and reverse the glutathionylation of eNOS induced by hyperglycemia, restoring its activity and NO levels, further confirming the potential of Grx1 in the treatment of diabetic CVDs [79]. Here, NOS3 is linked to Hyperglycemia.