To limit confounding factors, first adjusting for age, sex, BMI, hypertension, smoking, HbA1c, history of insulin use, history of RAAS inhibitor use, history of statin use and dyslipidemia (Model 1), high RC levels were still associated with a higher risk of ESKD in both continuous (HR = 1.489; 95% CI 1.138–1.949, p = 0.004) and categorical RC (HR = 3.323; 95% CI 1.489–7.418, p = 0.003). The gene discussed is INS; the disease is metabolic syndrome.