TNF and hepatitis B virus infection: Relevant comedication, such as cotrimoxazole for pneumocystis prophylaxis during treatment with cyclophosphamide or rituximab alongside prednisolone therapy[13], entecavir prophylaxis for hepatitis B status under rituximab therapy[14], antibiotic prophylaxis for latent tuberculosis and planned TNF inhibition[14] or vitamin D prophylaxis for prednisolone treatments[15], was sometimes, but not regularly recommended by the LLM (cases 5, 7, 13, 17–20).