The prognostic impact of certain genetic co‐mutations, including TET1/2, IDH1/2, DNMT3A, FLT3‐TKD, GATA2, and MDS‐related genes in NPM1mut AML patients is still not fully understood, and conflicting results have been reported in recent studies.15 This evidence concerns the gene TET1 and acute myeloid leukemia.