The prognostic impact of certain genetic co‐mutations, including TET1/2, IDH1/2, DNMT3A, FLT3‐TKD, GATA2, and MDS‐related genes in NPM1mut AML patients is still not fully understood, and conflicting results have been reported in recent studies.15 Here, DNMT3A is linked to acute myeloid leukemia.