For instance, ADAR2 targets intronic Alu elements of phosphatase cell division cycle 14B (CDC14B), an upstream regulator of S-phase kinase-associated protein 2 (Skp2)/p21/p27 pathway, in glioblastoma (GBM) (Galeano et al., 2013). Here, CDKN1A is linked to glioblastoma.