IGFBP7 and esophageal squamous cell carcinoma: ADAR2 also modifies the insulin-like growth factor binding protein 7 (IGFBP7) mRNA and stabilizes its protein by altering protease recognition site of matriptase (lysine-to-arginine at residue 95), which is essential for IGFBP7-induced apoptosis and the inhibition of Akt signaling in ESCC (Chen et al., 2017b).