A-to-I editing of miR-3144-3p (3_A < G) by ADAR1 in liver cancer drastically shifts the target specificity of this miRNA, with the defective target of its canonical mRNA target Musashi RBP 2 (MSI2, an oncogene), whereas generating gain-of-function binding to SLC38A4 mRNA (a tumor suppressor). Here, SLC38A4 is linked to neoplasm.