ADAR1 enhances the function of GLI1 through A-to-I editing that leads to a change from arginine to glycine at Position 701, which boosted GLI1 transcriptional activity and therefore pro-tumorigenic phenotypes in pancreatic ductal adenocarcinoma (Shen et al., 2021). This evidence concerns the gene GLI1 and pancreatic ductal adenocarcinoma.