PARVA and melanoma: In a similar vein, miR-378a-3p is edited by ADAR1 in nonmetastatic but not in metastatic melanoma cells, and the modified form of miR-378a-3p preferentially binds to 3ʹ-UTR of the alpha-parvin (PARVA) oncogene and suppresses its expression, thereby preventing progression of melanoma towards malignant phenotypes (Velazquez-Torres et al., 2018).