Edited FLNB reduces the tumor suppressive activities of the protein, thereby promoting growth and invasion in TNBC. ADAR1-downregulated miRNAs 27a-5p and miR-4485-3p inhibit cell-cycle progression, and that miR-27a-5p also suppresses invasion and promotes IL6/TNF expression in TNBC cells. Here, IL6 is linked to neoplasm.