GABRA3 and breast cancer: In contrast to the prevailing notion that ADAR1-mediated recoding is largely pro-tumorigenic in nature, one report demonstrated that ADAR1p110-mediated A-to-I recoding of GABRA3 (isoleucine-to-methionine at Position 342) repressed GABRA3-mediated AKT signaling, leading to reduced cell migration and invasion in BC (Gumireddy et al., 2016).