In our previous study on CH, TNFα increased the levels of two components of the 20 Score proteasome complex (PSMA6 and PSMB4), which is a component of the proteasome regulatory system (PSMD10) and of the ubiquitin-conjugating enzyme E2 K (UBE2K) [11]. The gene discussed is UBE2K; the disease is cyclic hematopoiesis.