Although EoE and IBD, particularly UC, invoke Th2-mediated pathways with shared pro-inflammatory cytokines (mainly IL-5 and IL-13) and shared activation of downstream Janus kinase and signal transducer and activator of transcription (JAK-STAT) pathways (mainly STAT3 and STAT6), they have distinct genetic landscapes. This evidence concerns the gene STAT6 and inflammatory bowel disease.