Previously, we discovered that TKI-activated NFκB2 is the key regulator of C-X-C motif chemokine ligand (CXCL)/CXC receptor 2 (CXCR2)-mediated inflammatory pathways in promoting the survival and relapse of FLT3-mut AML blasts ex vivo [9]. This evidence concerns the gene FLT3 and acute myeloid leukemia.